Japanese Knotweed--Invasive Weed or Plant Ally?

by Ella Akers. Medically Reviewed by Jenny Wheeler MD

Japanese knotweed (Latin name Polygonum cuspidatum) is a perennial plant native to Eastern Asia that was introduced to North America in the late nineteenth century. It grows in moist areas with full or partial sun and is often mistaken as a type of bamboo. Japanese knotweed has a reputation for being “invasive”; it’s largely viewed as a nuisance that takes over land. However, it is actually an incredibly useful plant. The roots contain high concentrations of the chemical compounds resveratrol and trans-resveratrol, which have immense health benefits.

Although resveratrol and trans-resveratrol act similarly in the body, there are differences between the two. One of the most significant differences is that trans-resveratrol is more bioavailable than regular resveratrol, meaning it is easier for the body to absorb and use. Both compounds demonstrate antiviral and antibacterial properties. They support immune function and have even been shown to have anticarcinogenic (anti-cancer) potential.

Perhaps one of the most notable actions of these compounds is their capacity in combating Lyme disease. Lyme is most often caused by the bacterium Borrelia burgdorferi, which may be transmitted to humans through the bite of infected ticks. Borrelia burgdorferi is a type of bacterium called a spirochete. Lyme spirochetes can wreak havoc in the body, potentially leading to the development of conditions such as arthritis and carditis (heart inflammation). In extreme cases, encephalopathy (brain disease) may occur. Resveratrol and trans-resveratrol are anti-spirochetal; they help the body fight Lyme bacteria, thus reducing its negative effects. Manufactured supplements containing resveratrol and/or trans-resveratrol can be purchased, but Japanese knotweed is an accessible and abundant natural source. What’s more, it’s very plentiful throughout New England.

Cautions and contraindications: Contraindicated in pregnancy. Caution peri-operatively and if taking any blood thinning agents.

References

Tatum, R., & Pearson-Shaver, A. L. (2023, July 17). Borrelia burgdorferi - StatPearls -

NCBI Bookshelf. National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK532894/#:~:text=Borrelia%20burgdorferi%20is%20a%20pathogenic,and%20in%20late%20stages%2C%20encephalopathy.

Buhner, S. H., Nathan, N., & Buhner, S. H. (2015). Polygonum cuspidatum. In Healing lyme:

Natural healing of lyme borreliosis and the coinfections chlamydia and Spotted Fever Rickettsioses (pp. 336–352). Raven Press.

Rawls, W. (2017a). Herbal Antimicrobials. In Unlocking Lyme: myths, truths, and practical

solutions for Chronic Lyme Disease. FirstDoNoHarm Publishing.